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Block C4 - Adolescence and Adulthood

Pathological Anatomy
Office:4th floor, Radiopoetro
Lab:4th floor, Radiopoetro
Pre-test:10 multiple-choice questions.
Post-test:5-10 written questions.
Lab Report:Yes.

Fibroadenoma of the Breast[edit]

  • Benign tumor.
  • Encapsulated.
  • Not painful.
  • Movable.
  • Common below age 30.
  • Usually solitary and unilateral. (Just one tumor, on just one side).
  • Lots of ducts visible:
    • Pericanalicular: round shape and empty lumen.
    • Intracanalicular: shaped like branches.

Fibrocystic Lesion of the Breast[edit]

Apocrine metaplasia in a fibrocystic lesion
  • Common between ages 20 to 40.
  • Often multiple and bilateral.
  • Usually upper, outer quadrant of the breast.
  • Painful: dull, heavy pain and tenderness on palpation.
  • Blue dome cyst.
  • Dominated by lymphocytes and plasma cells.
  • May be caused by estrogen/hormonal imbalance.
  • No fibrous capsule.
  • Apocrine metaplasia.

Ductal Infiltrative Carcinoma (DIC) of the Breast[edit]

Ductal Infiltrative Carcinoma
  • Originates from ductal epithelium (adenocarcinoma).
  • Metastasizes usually via lymphatic system but sometimes via blood vessels too.
  • Signs:
    • Fixed mass.
    • Skin retraction.
    • Nipple retraction.
    • P'eau de orange: due to obstruction of lymph flow.
    • Metastasizes to axillary lymph nodes.
  • Common beyond age 20.
  • Painful.
  • Tumor may have comedo (a ductal tumor with central necrosis).

Phyllodes Tumor of the Breast[edit]

Phyllodes Tumor
  • Looks leaf-like.
  • Originates from intralobular stroma.
  • Rarely metastasize.
  • Cellular stroma composed of atypical spindle cells.


Batch 2011 Pretest[edit]

Batch 2011 pretest